Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 0.50 |
| ▸ | HTR1B | P28222 | 19/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8470712 | 0.93 | HTR1D (0.51) | HTR1DHTR1B | |
| SCHEMBL8472475 | 0.88 | HTR1D (0.52) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8470626 | 0.88 | HTR1D (0.57) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8471236 | 0.86 | HTR1D (0.54) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8470504 | 0.86 | HTR1D (0.53) | HTR1DHTR1B | |
| SCHEMBL8473418 | 0.85 | HTR1D (0.58) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8470917 | 0.85 | HTR1D (0.47) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8473585 | 0.84 | HTR1D (0.55) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8472304 | 0.82 | HTR1D (0.51) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL8471595 | 0.81 | HTR1D (0.57) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | claimed |
| US-5925638-A | Substituted 1-indolylpropyl-4-benzylpiperazine derivatives | MERCK SHARP & DOHME LTD. (GB) | 1999-07-20 | — | — | US | disclosed |