Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537797 | 1.00 | MAPT (0.59) | MAPTLMNAAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL6538193 | 0.82 | MAPT (0.70) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6538195 | 0.82 | MAPT (0.70) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6300775 | 0.80 | SMN1; SMN2 (0.53) | MAPTLMNAAKR1C3AKR1C2AKR1B10 | |
| Oxalic Acid SCHEMBL20984441 | 0.80 | AKR1C3 (0.60) | MAPTAKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL8524918 | 0.80 | MAPT (0.50) | MAPTMAPK1ALDH1A1BACE1 | |
| SCHEMBL6537432 | 0.80 | MAPT (0.50) | MAPTMAPK1ALDH1A1BACE1 | |
| SCHEMBL3496338 | 0.79 | SMN1; SMN2 (0.66) | MAPTAKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL3496332 | 0.79 | SMN1; SMN2 (0.66) | MAPTAKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL1511316 | 0.76 | SMN1; SMN2 (0.66) | MAPTLMNAAKR1C3AKR1C2AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |