Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 10/20 | 0.47 |
| ▸ | CA2 | P00918 | 10/20 | 0.47 |
| ▸ | CA4 | P22748 | 10/20 | 0.47 |
| ▸ | CA9 | Q16790 | 10/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8475749 | 0.96 | TACR1 (0.57) | TACR1ABCB1CA1CA2CA4 | |
| SCHEMBL8475742 | 0.96 | TACR1 (0.57) | TACR1ABCB1CA1CA2CA4 | |
| SCHEMBL8478382 | 0.93 | TACR1 (0.55) | TACR1ABCB1CA1CA2CA4 | |
| SCHEMBL8478388 | 0.93 | TACR1 (0.55) | TACR1ABCB1CA1CA2CA4 | |
| SCHEMBL8479386 | 0.92 | TACR1 (0.53) | TACR1ABCB1CA1CA2CA4 | |
| SCHEMBL8479384 | 0.92 | TACR1 (0.53) | TACR1ABCB1CA1CA2CA4 | |
| SCHEMBL8478269 | 0.91 | TACR1 (0.54) | TACR1ABCB1CA1CA2CA4 | |
| SCHEMBL8480864 | 0.91 | TACR1 (0.54) | TACR1ABCB1CA1CA2CA4 | |
| SCHEMBL8478266 | 0.91 | TACR1 (0.54) | TACR1ABCB1CA1CA2CA4 | |
| SCHEMBL8480494 | 0.91 | TACR1 (0.54) | TACR1ABCB1CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883098-A | USED AS TACHYKININ ANTAGONISTS IN THE TREATMENT OF RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND INFLAMMATORY DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5670505-A | TACHYKIKIN ANTAGONIST FOR RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| EP-0655442-A1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |