Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | P4HB | P07237 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EBP | Q15125 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501732 | 1.00 | ESR1 (0.58) | ESR1ESR2SIGMAR1MEN1P4HB | |
| SCHEMBL8475692 | 1.00 | ESR1 (0.58) | ESR1ESR2SIGMAR1MEN1P4HB | |
| SCHEMBL8475681 | 1.00 | ESR1 (0.58) | ESR1ESR2SIGMAR1MEN1P4HB | |
| SCHEMBL8504742 | 0.93 | ESR1 (0.49) | ESR1ESR2SIGMAR1MEN1P4HB | |
| SCHEMBL8480534 | 0.93 | ESR1 (0.49) | ESR1ESR2SIGMAR1MEN1P4HB | |
| SCHEMBL8480530 | 0.93 | ESR1 (0.49) | ESR1ESR2SIGMAR1MEN1P4HB | |
| SCHEMBL8480537 | 0.93 | ESR1 (0.49) | ESR1ESR2SIGMAR1MEN1P4HB | |
| SCHEMBL8480159 | 0.88 | ESR1 (0.66) | ESR1ESR2ADRA2AADRA2CHRH3 | |
| SCHEMBL8504829 | 0.88 | ESR1 (0.66) | ESR1ESR2ADRA2AADRA2CHRH3 | |
| SCHEMBL8480162 | 0.88 | ESR1 (0.66) | ESR1ESR2ADRA2AADRA2CHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937061-A1 | NOVEL $i(CIS)-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1999-08-25 | — | — | EP | claimed |
| WO-1998018777-A1 | NOVEL CIS-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-05-07 | — | — | WO | claimed |
| EP-0937061-A1 | NOVEL $i(CIS)-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1999-08-25 | — | — | EP | disclosed |
| US-5919817-A | NOVEL HYDROXY SUBSTITUTED CIS-3,4-DI((SUBSTITUTED)PHENYL) CHROMANE DERIVATIVES | NOVO NORDISK A/S (DK) | 1999-07-06 | — | — | US | disclosed |
| WO-1998018777-A1 | NOVEL CIS-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-05-07 | — | — | WO | disclosed |