Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 12/20 | 0.65 |
| ▸ | CA2 | P00918 | 12/20 | 0.65 |
| ▸ | CA4 | P22748 | 12/20 | 0.65 |
| ▸ | CA9 | Q16790 | 12/20 | 0.65 |
| ▸ | TACR1 | P25103 | 7/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100617 | 0.90 | TACR1 (0.61) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL8481073 | 0.90 | TACR1 (0.61) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL8480544 | 0.89 | TACR1 (0.63) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL8476168 | 0.89 | TACR1 (0.60) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL8480058 | 0.88 | CA1 (0.66) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL8482237 | 0.88 | TACR1 (0.59) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL9241572 | 0.87 | TACR1 (0.58) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL8479852 | 0.87 | TACR1 (0.58) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL9241579 | 0.87 | TACR1 (0.58) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL8475431 | 0.87 | TACR1 (0.60) | CA1CA2CA4CA9TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883098-A | USED AS TACHYKININ ANTAGONISTS IN THE TREATMENT OF RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND INFLAMMATORY DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5670505-A | TACHYKIKIN ANTAGONIST FOR RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| EP-0655442-A1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |