Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MITF | O75030 | 1/20 | 0.65 |
| ▸ | XBP1 | P17861 | 1/20 | 0.65 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.65 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.65 |
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847083 | 0.84 | KDR (0.84) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846564 | 0.82 | MEN1 (0.58) | KDRNPC1RAB9AKDM4ETRPV1 | |
| SCHEMBL847442 | 0.81 | KDR (0.66) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL995474 | 0.81 | KDR (1.00) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL29647749 | 0.80 | KDR (0.81) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846685 | 0.80 | KDR (0.81) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL19616459 | 0.80 | KDR (0.81) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846300 | 0.79 | KDR (0.67) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846074 | 0.79 | KDR (0.67) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846030 | 0.79 | KDR (0.67) | KDRNPC1RAB9AKDM4EMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |