Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.63 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | EBP | Q15125 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472437 | 0.86 | ESR1 (0.73) | ESR1ESR2LTA4HMCHR1EBP | |
| SCHEMBL7107091 | 0.85 | ESR1 (0.66) | ESR1ESR2LTA4HMCHR1EBP | |
| SCHEMBL8478033 | 0.83 | ESR1 (0.68) | ESR1ESR2LTA4HMCHR1PSMB1 | |
| SCHEMBL8472940 | 0.83 | ESR1 (0.58) | ESR1ESR2LTA4HMCHR1PSMB1 | |
| SCHEMBL8578487 | 0.82 | ESR1 (0.65) | ESR1ESR2LTA4HEBPSIGMAR1 | |
| SCHEMBL8472430 | 0.82 | ESR1 (0.71) | ESR1ESR2LTA4HMCHR1EBP | |
| SCHEMBL11191615 | 0.80 | ESR1 (0.79) | ESR1ESR2LTA4HMCHR1EBP | |
| SCHEMBL8477440 | 0.80 | ESR1 (0.68) | ESR1ESR2EBPSIGMAR1PSMB1 | |
| SCHEMBL3870510 | 0.80 | ESR1 (0.82) | ESR1ESR2LTA4HMCHR1EBP | |
| SCHEMBL11185809 | 0.80 | ESR1 (0.82) | ESR1ESR2LTA4HMCHR1EBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958916-A | FOR INHIBITING BONE LOSS OR BONE RESORPTION | ELI LILLY AND COMPANY (US) | 1999-09-28 | — | — | US | disclosed |