Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | PDE6C | P51160 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990515 | 0.96 | PDE5A (0.68) | PDE5APOLBPDE6CPDE3BPDE3A | |
| SCHEMBL8502132 | 0.92 | PDE5A (0.64) | PDE5APOLBPDE6CHDAC1HDAC2 | |
| SCHEMBL8503916 | 0.91 | POLB (0.76) | PDE5APOLBPDE6CPDE3BPDE3A | |
| SCHEMBL8504153 | 0.91 | PDE5A (0.75) | PDE5APOLBPDE6CHDAC1HDAC6 | |
| SCHEMBL13065811 | 0.91 | PDE5A (0.69) | PDE5APOLBPDE6CPDE3BPDE3A | |
| SCHEMBL8512077 | 0.91 | PDE5A (0.66) | PDE5APOLBPDE6C | |
| SCHEMBL13990504 | 0.90 | PDE5A (0.69) | PDE5APOLBPDE6CPDE3BPDE3A | |
| SCHEMBL8490889 | 0.89 | PDE5A (0.67) | PDE5APOLBPDE6CPDE3BPDE3A | |
| SCHEMBL8479728 | 0.89 | POLB (0.64) | PDE5APOLBPDE6CHDAC1HDAC6 | |
| SCHEMBL8488497 | 0.89 | POLB (0.68) | PDE5APOLBPDE6CPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253632-B1 | Pyrazolopyramidinone derivatives, their preparation and their use | TOPHARMAN SHANGHAI CO LTD (CN) | 2012-05-23 | — | — | EP | disclosed |
| EP-2253632-A1 | Pyrazolopyramidinone derivatives, their preparation and their use | Topharman Shanghai Co., Ltd. (CN) | 2010-11-24 | — | — | EP | disclosed |
| EP-1961753-A1 | PYRAZOLOPYRIMIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Topharman Shanghai Co., Ltd. (CN) | 2008-08-27 | — | — | EP | disclosed |