Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.80 |
| ▸ | PIK3CG | P48736 | 19/20 | 0.80 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.80 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8482524 | 0.90 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL8487556 | 0.90 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL13063153 | 0.89 | PIK3CD (0.71) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL8487756 | 0.89 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL8482342 | 0.89 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL6122147 | 0.89 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL8480215 | 0.89 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL13063170 | 0.86 | PIK3CD (0.80) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL12974289 | 0.86 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL2717515 | 0.83 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068343-A1 | QUINOLINE DERIVATIVES AS PIK3 INHIBITORS | AMGEN INC. (US) | 2012-05-24 | — | — | WO | disclosed |