Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846968 | 0.89 | TRPV1 (0.67) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL13991492 | 0.87 | HDAC1 (0.72) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL846178 | 0.86 | MEN1 (0.60) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL13991505 | 0.85 | MEN1 (0.67) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL846038 | 0.84 | MEN1 (0.58) | MCHR1MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL1577038 | 0.83 | TRPV1 (0.76) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL846613 | 0.82 | TRPV1 (0.62) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL5776350 | 0.82 | MAPT (0.51) | MCHR1MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL4949897 | 0.82 | TRPV1 (0.53) | MCHR1MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL29432900 | 0.82 | CNR1 (0.57) | HDAC6TRPV1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |