SCHEMBL8484205

SCHEMBL8484205

O=C(O)CCCNC1CCC(Nc2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2)CC1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 14/20 0.65
ERBB2 P04626 7/20 0.65
HPGD P15428 1/20 0.65
HTT P42858 1/20 0.65
CSNK2A1 P68400 3/20 0.55
MAPT P10636 1/20 0.47
BRAF P15056 2/20 0.46
HDAC3 O15379 2/20 0.42
HDAC4 P56524 2/20 0.42
HDAC1 Q13547 2/20 0.42
HDAC7 Q8WUI4 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC10 Q969S8 2/20 0.42
HDAC11 Q96DB2 2/20 0.42
HDAC8 Q9BY41 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
HDAC9 Q9UKV0 2/20 0.42
HDAC5 Q9UQL6 2/20 0.42
BCL6 P41182 1/20 0.42
CSNK2A2 P19784 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8319333 0.89 EGFR (0.67) EGFRERBB2HPGDHTTCSNK2A1
SCHEMBL8319327 0.89 EGFR (0.67) EGFRERBB2HPGDHTTCSNK2A1
SCHEMBL7584824 0.88 EGFR (0.71) EGFRERBB2HPGDHTTCSNK2A1
SCHEMBL7584804 0.88 EGFR (0.71) EGFRERBB2HPGDHTTCSNK2A1
SCHEMBL7579210 0.88 EGFR (0.72) EGFRERBB2HPGDHTTCSNK2A1
SCHEMBL7588551 0.87 EGFR (0.63) EGFRERBB2HPGDHTTCSNK2A1
SCHEMBL7588562 0.87 EGFR (0.63) EGFRERBB2HPGDHTTCSNK2A1
SCHEMBL8314263 0.86 EGFR (0.84) EGFRERBB2HPGDHTTCSNK2A1
SCHEMBL7585267 0.86 EGFR (0.65) EGFRERBB2HPGDHTTCSNK2A1
SCHEMBL7585249 0.86 EGFR (0.65) EGFRERBB2HPGDHTTCSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5977102-A INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; DR. KARL THOMAE GMBH (DE) 1999-11-02 US disclosed
EP-0885227-A1 PYRIMIDO 5,4-d]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION Dr. Karl Thomae GmbH (DE) 1998-12-23 EP disclosed
WO-1997032882-A1 PYRIMIDO[5,4-d]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION DR. KARL THOMAE GMBH (DE) 1997-09-12 WO disclosed