Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.76 |
| ▸ | NPC1 | O15118 | 4/20 | 0.76 |
| ▸ | RAB9A | P51151 | 4/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | ATM | Q13315 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | MAOA | P21397 | 4/20 | 0.65 |
| ▸ | MAOB | P27338 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484340 | 1.00 | MAPT (0.76) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL25232280 | 0.88 | MAPT (0.76) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL25193659 | 0.88 | MAPT (0.76) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL25185071 | 0.88 | MAPT (0.76) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL25196901 | 0.88 | MAPT (0.76) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL23086310 | 0.86 | MAPT (0.88) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL23086308 | 0.86 | MAPT (0.88) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8485080 | 0.86 | MAPT (1.00) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8485074 | 0.86 | MAPT (1.00) | MAPTNPC1RAB9AMEN1KMT2A | |
| 4,4'-Dimethylchalcone SCHEMBL979559 | 0.85 | MAPT (1.00) | MAPTRAB9AMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922743-A | USEFUL FOR AMELIORATION OF NERVE DISORDERS DUE TO NEURONAL DEGENERATION, SUCH AS INDUCED BY DRUGS OR ALCOHOL, INFLAMMATORY DISORDERS, DIABETES, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, HUNTINGTON'S CHOREA, AND OTHERS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1999-07-13 | — | — | US | disclosed |
| EP-0795545-A1 | PYRIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1997-09-17 | — | — | EP | disclosed |