Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973191 | 0.97 | PDE5A (0.47) | PDE5A | |
| SCHEMBL14283367 | 0.92 | PDE5A (0.45) | PDE5A | |
| SCHEMBL4977859 | 0.92 | PDE5A (0.52) | PDE5A | |
| SCHEMBL4977151 | 0.89 | PDE5A (0.53) | PDE5A | |
| SCHEMBL8507723 | 0.86 | PDE5A (0.56) | PDE5A | |
| SCHEMBL4977802 | 0.82 | PDE5A (0.42) | PDE5A | |
| SCHEMBL4980820 | 0.81 | PDE5A (0.41) | PDE5A | |
| SCHEMBL4980096 | 0.81 | PDE5A (0.56) | PDE5A | |
| SCHEMBL4976224 | 0.81 | PDE5A (0.53) | PDE5A | |
| SCHEMBL4976300 | 0.80 | PDE5A (0.54) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273868-B2 | Pyrazine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 2007-09-25 | — | — | US | disclosed |
| US-7273868-B2 | Pyrazine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 2007-09-25 | — | — | US | disclosed |
| US-7220736-B2 | Pyrimidine compounds | TANABE SEIYAKU CO., LTD. (JP) | 2007-05-22 | — | — | US | disclosed |
| US-7220736-B2 | Pyrimidine compounds | TANABE SEIYAKU CO., LTD. (JP) | 2007-05-22 | — | — | US | disclosed |
| EP-1277741-A1 | CYCLIC COMPOUNDS | TANABE SEIYAKU CO., LTD. (JP) | 2003-01-22 | — | — | EP | disclosed |