SCHEMBL8485232

SCHEMBL8485232

CC(C)(C)[Si](Oc1cccc2c1CCC(CCOC(=O)N(c1ccccc1)c1ccccc1)=C2)(c1ccccc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 7/20 0.38
PTGDR Q13258 3/20 0.38
PTGER1 P34995 1/20 0.38
PTGER3 P43115 1/20 0.38
CHRM4 P08173 1/20 0.30
CHRM5 P08912 1/20 0.30
CHRM1 P11229 1/20 0.30
CHRM3 P20309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7776701 0.91 PTGIR (0.37) PTGIRPTGDRPTGER1PTGER3CHRM4
SCHEMBL7718275 0.85 PTGIR (0.36) PTGIRPTGDRPTGER1PTGER3CHRM4
SCHEMBL7772465 0.80 PTGIR (0.42) PTGIRPTGDRPTGER1PTGER3
SCHEMBL7779651 0.79 PTGIR (0.35) PTGIR
SCHEMBL7779678 0.78 PTGIR (0.39) PTGIRPTGDRPTGER1PTGER3CHRM4
SCHEMBL8487303 0.77 PTGIR (0.45) PTGIRPTGDRPTGER1PTGER3
SCHEMBL8481589 0.77 PTGIR (0.56) PTGIRPTGDRPTGER1PTGER3CHRM4
SCHEMBL7776620 0.76 PTGIR (0.67) PTGIRPTGDRPTGER1PTGER3CHRM4
SCHEMBL7778395 0.76 PTGIR (0.67) PTGIRPTGDRPTGER1PTGER3CHRM4
SCHEMBL7778597 0.76 PTGIR (0.40) PTGIRPTGDRPTGER1PTGER3CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5863918-A HYPOTENSIVE AGENTS, ANTICOAGULANTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-01-26 US disclosed
US-5763489-A ANTICOAGULANTS AND HYPOTENSIVE AGENTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-09 US disclosed