Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483681 | 0.95 | EGFR (0.64) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8483488 | 0.93 | EGFR (0.62) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6994175 | 0.92 | EGFR (0.69) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6994172 | 0.92 | EGFR (0.69) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6999566 | 0.91 | EGFR (0.72) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6999193 | 0.89 | EGFR (0.65) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6994831 | 0.88 | EGFR (0.61) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8313711 | 0.88 | EGFR (0.63) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8313712 | 0.88 | EGFR (0.63) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL7000242 | 0.87 | EGFR (0.67) | EGFRERBB2HPGDHTTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977102-A | INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; | DR. KARL THOMAE GMBH (DE) | 1999-11-02 | — | — | US | disclosed |