Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 10/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8482003 | 0.93 | TOP2A (0.39) | TOP2ATOP2BDYRK1AKDM4CATR | |
| SCHEMBL8484357 | 0.91 | TOP2A (0.46) | TOP2ATOP2BDYRK1AEGFR | |
| SCHEMBL8487456 | 0.90 | DYRK1A (0.35) | TOP2ATOP2BDYRK1A | |
| SCHEMBL8486549 | 0.88 | DYRK1A (0.36) | TOP2ATOP2BDYRK1A | |
| SCHEMBL8483443 | 0.85 | TOP2A (0.43) | TOP2ATOP2BDYRK1A | |
| SCHEMBL8483090 | 0.84 | TOP2A (0.48) | TOP2ATOP2BDYRK1AKDM4CEGFR | |
| SCHEMBL8482764 | 0.83 | TOP2A (0.34) | TOP2ATOP2B | |
| SCHEMBL8488681 | 0.82 | DYRK1A (0.36) | TOP2ATOP2BDYRK1ACYP3A4 | |
| SCHEMBL8485118 | 0.82 | CYP2D6 (0.36) | TOP2ATOP2BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10921806 | 0.79 | TOP2A (0.50) | TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935969-A | Pyrido-thiopyrandoinazoles with antitumor activity | UNIVERSITY OF VERMONT (US) | 1999-08-10 | — | — | US | disclosed |