Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9189552 | 1.00 | KDM4E (0.58) | KDM4ETDP1ALOX15HSD17B10USP2 | |
| SCHEMBL9189547 | 1.00 | KDM4E (0.58) | KDM4ETDP1ALOX15HSD17B10USP2 | |
| SCHEMBL10599133 | 0.90 | HSD17B10 (0.51) | KDM4ETDP1ALOX15HSD17B10USP2 | |
| SCHEMBL10599130 | 0.90 | HSD17B10 (0.51) | KDM4ETDP1ALOX15HSD17B10USP2 | |
| SCHEMBL10599118 | 0.90 | HSD17B10 (0.51) | KDM4ETDP1ALOX15HSD17B10USP2 | |
| SCHEMBL11018324 | 0.90 | POLB (0.53) | KDM4ETDP1ALOX15HSD17B10USP2 | |
| SCHEMBL11018327 | 0.90 | POLB (0.53) | KDM4ETDP1ALOX15HSD17B10USP2 | |
| SCHEMBL10898993 | 0.90 | POLB (0.53) | KDM4ETDP1ALOX15HSD17B10USP2 | |
| SCHEMBL11021133 | 0.89 | POLB (0.58) | KDM4ETDP1ALOX15HSD17B10USP2 | |
| SCHEMBL11021134 | 0.89 | POLB (0.58) | KDM4ETDP1ALOX15HSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883264-A | SUBJECTING RACEMIC TRANS-3-PHENYLGLYCIDAMIDE COMPOUND TO OPTICAL RESOLUTION USING A MICROORGANISM HAVING ABILITY OF PREFERENTIALLY HYDROLYZING ONE OF (2S,3R) ISOMER OR (2R,3S) ISOMER THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5847122-A | Process for preparing 1,5-benzothiazepine derivative | TANABE SEIYAKU CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0795609-A2 | Process for preparing optically active trans-3-phenylglycidamide compounds | TANABE SEIYAKU CO., LTD. (JP) | 1997-09-17 | — | — | EP | disclosed |
| EP-0792876-A2 | Process for preparing 1,5-benzothiazepine derivative | TANABE SEIYAKU CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| EP-0395302-B1 | Process for preparing 1,5-benzothiazepine derivatives | TANABE SEIYAKU CO (JP) | 1995-01-04 | — | — | EP | disclosed |
| EP-0612737-A1 | Process for preparing 1,5-benzothiazepine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |
| US-5310904-A | Intermediate | TANABE SEIYAKU CO., LTD. (JP) | 1994-05-10 | — | — | US | disclosed |
| EP-0551076-A1 | Process for preparing optically active benzothiazepine compounds by asymmetric reduction | TANABE SEIYAKU CO., LTD. (JP) | 1993-07-14 | — | — | EP | disclosed |
| US-5128469-A | Catalytic ring closure with organic sulfonic acid; amidation | TANABE SEIYAKU CO., LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| US-5055575-A | Process for preparing 1,5-benzothiazepine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0395302-A1 | Process for preparing 1,5-benzothiazepine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1990-10-31 | — | — | EP | disclosed |
| EP-0158340-B1 | NOVEL 1,5-BENZOTHIAZEPINE DERIVATIVE, PROCESSES FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS | Tanabe Seiyaku Co., Ltd. (JP) | 1989-01-18 | — | — | EP | disclosed |
| US-4594342-A | Anticoagulants | TANABE SEIYAKU CO., LTD. (JP) | 1986-06-10 | — | — | US | disclosed |
| EP-0158340-A2 | Novel 1,5-benzothiazepine derivative, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1985-10-16 | — | — | EP | disclosed |