Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 14/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | YES1 | P07947 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | FGR | P09769 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486027 | 0.86 | TOP2A (0.32) | TOP2A | |
| SCHEMBL8486726 | 0.85 | TOP2A (0.32) | TOP2ATOP2B | |
| SCHEMBL8483875 | 0.84 | KDM1A (0.34) | TOP2ATOP2BGSK3BSMN1; SMN2KDM4E | |
| SCHEMBL10925471 | 0.84 | TOP2A (0.39) | TOP2ATOP2BSMN1; SMN2KDM4EKDM1A | |
| SCHEMBL8485663 | 0.80 | TOP2A (0.46) | TOP2A | |
| SCHEMBL8721611 | 0.79 | TOP2A (0.49) | TOP2ATOP2B | |
| SCHEMBL8485118 | 0.79 | CYP2D6 (0.36) | TOP2ATOP2BNQO1GSK3B | |
| SCHEMBL8483006 | 0.79 | TOP2A (0.37) | TOP2ATOP2BNQO1GSK3B | |
| SCHEMBL8721606 | 0.79 | TOP2A (0.35) | TOP2ATOP2B | |
| SCHEMBL10812739 | 0.78 | CYP1A2 (0.40) | TOP2ATOP2BNQO1GSK3BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935969-A | Pyrido-thiopyrandoinazoles with antitumor activity | UNIVERSITY OF VERMONT (US) | 1999-08-10 | — | — | US | disclosed |