Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370365 | 0.91 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL5365073 | 0.90 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL5358848 | 0.88 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL5361540 | 0.88 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL5362716 | 0.87 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL5362615 | 0.87 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPOLB | |
| Bicarbonate SCHEMBL6172538 | 0.86 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL6433473 | 0.86 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL920657 | 0.86 | POLB (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL6804123 | 0.86 | HPGD (0.46) | PDE4APDE4BPDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229034-B1 | Nicotinamide derivatives and their mimetics as inhibitors of PDE4 isozymes | PFIZER PROD INC (US) | 2005-04-13 | — | — | EP | disclosed |