Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487455 | 1.00 | EGFR (0.57) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8486781 | 0.89 | EGFR (0.57) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8488224 | 0.88 | EGFR (0.74) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8316770 | 0.84 | EGFR (0.77) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6997208 | 0.84 | EGFR (0.77) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6997215 | 0.84 | EGFR (0.77) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8487099 | 0.83 | EGFR (0.54) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8487101 | 0.83 | EGFR (0.54) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8485773 | 0.81 | EGFR (0.73) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8485770 | 0.81 | EGFR (0.73) | EGFRERBB2HPGDHTTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977102-A | INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; | DR. KARL THOMAE GMBH (DE) | 1999-11-02 | — | — | US | disclosed |