Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 14/20 | 0.78 |
| ▸ | USP7 | Q93009 | 8/20 | 0.78 |
| ▸ | USP47 | Q96K76 | 4/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1512485 | 0.88 | USP8 (1.00) | USP8USP7USP47ALDH1A1MAPT | |
| SCHEMBL30931160 | 0.88 | USP8 (1.00) | USP8USP7USP47ALDH1A1MAPT | |
| SCHEMBL1512515 | 0.84 | USP8 (0.92) | USP8USP7USP47ALDH1A1MAPT | |
| SCHEMBL1512371 | 0.81 | USP8 (0.78) | USP8USP7USP47ALDH1A1MAPT | |
| SCHEMBL1512546 | 0.81 | USP8 (1.00) | USP8USP7USP47ALDH1A1MAPT | |
| SCHEMBL1512518 | 0.81 | USP8 (0.78) | USP8USP7USP47ALDH1A1MAPT | |
| SCHEMBL8471588 | 0.81 | USP8 (0.50) | USP8USP7USP47ALDH1A1CYP1A2 | |
| SCHEMBL1512437 | 0.80 | USP8 (0.71) | USP8USP7USP47ALDH1A1MAPT | |
| SCHEMBL13751740 | 0.80 | USP8 (0.71) | USP8USP7USP47ALDH1A1MAPT | |
| SCHEMBL1512549 | 0.80 | USP8 (1.00) | USP8USP7USP47ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912954-B1 | NOVEL CYSTEINE PROTEASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2011-03-09 | — | — | EP | disclosed |
| EP-1749822-B1 | Novel cysteine protease inhibitors and their therapeutic applications | HYBRIGENICS SA (FR) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007017758-A2 | NOVEL CYSTEINE PROTEASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2007-02-15 | — | — | WO | disclosed |