SCHEMBL8487538

SCHEMBL8487538

CCCc1ccc(F)c(C=O)c1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCI P41743 1/20 0.44
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
ERN1 O75460 2/20 0.38
ELANE P08246 2/20 0.37
CTSG P08311 1/20 0.37
CTSL P07711 1/20 0.34
CTSS P25774 1/20 0.34
CTSK P43235 1/20 0.34
LMNA P02545 2/20 0.33
TYR P14679 2/20 0.33
MAPT P10636 1/20 0.33
XBP1 P17861 1/20 0.33
HIF1A Q16665 1/20 0.33
ALOX5 P09917 1/20 0.33
HSD17B3 P37058 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5337847 0.85 PRKCI (0.49) PRKCIELANECTSGLMNATYR
SCHEMBL23106595 0.81 ERN1 (0.41) CYP3A4CYP2C9CYP2C19ERN1
SCHEMBL28035774 0.81 PRKCI (0.45) PRKCICYP3A4ERN1ELANECTSG
SCHEMBL13563316 0.76 PRKCI (0.46) PRKCICYP3A4ELANECTSGTYR
SCHEMBL3962694 0.75 TYR (0.46) PRKCICYP3A4ELANECTSGLMNA
SCHEMBL1804679 0.75 ERN1 (0.56) CYP3A4CYP2C9CYP2C19ERN1
SCHEMBL29952205 0.75 ERN1 (0.56) CYP3A4CYP2C9CYP2C19ERN1
SCHEMBL13924219 0.74 PRKCI (0.44) PRKCICYP3A4ELANECTSGLMNA
SCHEMBL28035342 0.74 PRKCI (0.41) PRKCICYP3A4ERN1ELANECTSG
SCHEMBL14677973 0.72 TYR (0.51) PRKCICYP3A4ELANECTSGTYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100347164-C Benzofuryl derivatives and their use HOFMMANN LA ROCHE AG F (CH) 2007-11-07 CN disclosed
US-5955495-A BENZOFURAN-2-CARBOXAMIDINE OR 2-CARBOXAMIDOXIME COMPOUNDS USEFUL IN THE CONTROL OR PREVENTION OF ILLNESSES OR DISORDERS OF THE CENTRAL NERVOUS SYSTEM SUCH AS MIGRAINE, SCHIZOPHRENIA, ANXIETY STATES, SLEEP DISORDERS, ANOREXIA, ALZHEIMER'S HOFFMANN-LA ROCHE INC. (US) 1999-09-21 US disclosed
CN-1217720-A Benzofuryl derivatives and their use HOFMMANN LA ROCHE (CH) 1999-05-26 CN disclosed
EP-0906301-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1999-04-07 EP disclosed
WO-1997042183-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1997-11-13 WO disclosed