Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.58 |
| ▸ | CA1 | P00915 | 10/20 | 0.49 |
| ▸ | CA2 | P00918 | 10/20 | 0.49 |
| ▸ | CA4 | P22748 | 10/20 | 0.49 |
| ▸ | CA9 | Q16790 | 10/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | RHOA | P61586 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9236786 | 0.88 | TACR1 (0.44) | TACR1CA1CA2CA4CA9 | |
| SCHEMBL8475431 | 0.88 | TACR1 (0.60) | TACR1CA1CA2CA4CA9 | |
| SCHEMBL8482237 | 0.87 | TACR1 (0.59) | TACR1CA1CA2CA4CA9 | |
| SCHEMBL8476085 | 0.86 | TACR1 (0.58) | TACR1CA1CA2CA4CA9 | |
| SCHEMBL8480058 | 0.86 | CA1 (0.66) | TACR1CA1CA2CA4CA9 | |
| SCHEMBL8482171 | 0.85 | TACR1 (0.57) | TACR1CA1CA2CA4CA9 | |
| SCHEMBL8481073 | 0.85 | TACR1 (0.61) | TACR1CA1CA2CA4CA9 | |
| SCHEMBL6100617 | 0.85 | TACR1 (0.61) | TACR1CA1CA2CA4CA9 | |
| SCHEMBL8475754 | 0.84 | TACR1 (0.59) | TACR1 | |
| SCHEMBL7827053 | 0.84 | TACR1 (0.59) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883098-A | USED AS TACHYKININ ANTAGONISTS IN THE TREATMENT OF RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND INFLAMMATORY DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5670505-A | TACHYKIKIN ANTAGONIST FOR RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| EP-0655442-A1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |