Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994929 | 0.92 | EGFR (0.60) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6997525 | 0.92 | EGFR (0.67) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6995214 | 0.92 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8486621 | 0.90 | EGFR (0.57) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6997165 | 0.90 | EGFR (0.57) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6986980 | 0.90 | EGFR (0.57) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6998518 | 0.86 | EGFR (0.56) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6991387 | 0.85 | EGFR (0.77) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8487002 | 0.85 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6990908 | 0.84 | EGFR (0.58) | EGFRERBB2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977102-A | INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; | DR. KARL THOMAE GMBH (DE) | 1999-11-02 | — | — | US | disclosed |