Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.72 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.72 |
| ▸ | MAOA | P21397 | 2/20 | 0.72 |
| ▸ | HTR3A | P46098 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | SCN1A | P35498 | 4/20 | 0.68 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.68 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489298 | 0.85 | TSHR (0.74) | TSHRCYP2D6HRH3MAOAHTR3A | |
| SCHEMBL28853482 | 0.85 | CYP2D6 (0.74) | TSHRCYP2D6HRH3MAOAHTR3A | |
| SCHEMBL21705606 | 0.84 | TSHR (0.72) | TSHRCYP2D6HRH3MAOAHTR3A | |
| Procaine SCHEMBL3524 | 0.84 | CYP2D6 (1.00) | TSHRCYP2D6HRH3MAOAHTR3A | |
| SCHEMBL8487897 | 0.83 | PHLPP2 (0.71) | TSHRCYP2D6HRH3MAOAHTR3A | |
| SCHEMBL453815 | 0.83 | TSHR (0.71) | TSHRCYP2D6HRH3MAOAHTR3A | |
| SCHEMBL4903510 | 0.83 | TSHR (0.67) | TSHRCYP2D6HRH3MAOAHTR3A | |
| SCHEMBL11584964 | 0.83 | TSHR (0.70) | TSHRCYP2D6HRH3MAOAHTR3A | |
| Procaine SCHEMBL9050778 | 0.83 | CYP2D6 (0.97) | TSHRCYP2D6HRH3MAOAHTR3A | |
| Procaine SCHEMBL6061234 | 0.83 | CYP2D6 (0.97) | TSHRCYP2D6HRH3MAOAHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863913-A | ALLEVIATION OF RENAL DYSFUNCTION WITHOUT AFFECTING BLOOD PRESSURE AT A LOW BLOOD CONCENTRATION. | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1999-01-26 | — | — | US | disclosed |