Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8490032 | 0.93 | EGFR (0.57) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6994800 | 0.87 | EGFR (0.60) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6993122 | 0.85 | EGFR (0.60) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8483667 | 0.85 | EGFR (0.58) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6989432 | 0.84 | STK17A (0.62) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6990324 | 0.83 | STK17A (0.59) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6992551 | 0.82 | EGFR (0.59) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8488667 | 0.81 | CSNK2A1 (0.62) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8314941 | 0.80 | EGFR (0.55) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6993332 | 0.80 | EGFR (0.59) | EGFRERBB2HPGDHTTGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977102-A | INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; | DR. KARL THOMAE GMBH (DE) | 1999-11-02 | — | — | US | disclosed |