Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.81 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.64 |
| ▸ | TFEB | P19484 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TLR4 | O00206 | 1/20 | 0.57 |
| ▸ | TLR2 | O60603 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8491329 | 1.00 | HTT (0.81) | HTTGAANFE2L2TFEBLMNA | |
| SCHEMBL1006523 | 0.89 | HTT (1.00) | HTTGAANFE2L2TFEBLMNA | |
| SCHEMBL6714231 | 0.89 | HTT (1.00) | HTTGAANFE2L2TFEBLMNA | |
| Hydrochloric Acid SCHEMBL11180824 | 0.88 | HTT (0.97) | HTTGAANFE2L2TFEBLMNA | |
| SCHEMBL11180817 | 0.86 | HTT (0.76) | HTTGAANFE2L2TFEBLMNA | |
| SCHEMBL9185939 | 0.86 | HTT (0.76) | HTTGAANFE2L2TFEBLMNA | |
| SCHEMBL9185934 | 0.86 | HTT (0.76) | HTTGAANFE2L2TFEBLMNA | |
| SCHEMBL30584121 | 0.86 | HTT (0.76) | HTTGAANFE2L2TFEBLMNA | |
| SCHEMBL7770107 | 0.83 | HTT (0.71) | HTTGAANFE2L2TFEBLMNA | |
| SCHEMBL15065737 | 0.83 | HTT (0.71) | HTTGAALMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |