Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 6/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 4/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015014 | 1.00 | SERPINE1 (0.55) | SERPINE1CHEK2BCHEACHEIKBKB | |
| SCHEMBL8492151 | 1.00 | SERPINE1 (0.55) | SERPINE1CHEK2BCHEACHEIKBKB | |
| SCHEMBL8495273 | 0.89 | SERPINE1 (0.59) | SERPINE1HRH3ALDH1A1DNM1MAOB | |
| SCHEMBL8495305 | 0.89 | SERPINE1 (0.59) | SERPINE1HRH3ALDH1A1DNM1MAOB | |
| SCHEMBL8492103 | 0.88 | SERPINE1 (0.59) | SERPINE1BCHEACHEHRH3ALDH1A1 | |
| SCHEMBL8492094 | 0.88 | SERPINE1 (0.59) | SERPINE1BCHEACHEHRH3ALDH1A1 | |
| SCHEMBL8496911 | 0.86 | SERPINE1 (0.55) | SERPINE1HRH3ALDH1A1DNM1MAOB | |
| SCHEMBL8496917 | 0.86 | SERPINE1 (0.55) | SERPINE1HRH3ALDH1A1DNM1MAOB | |
| SCHEMBL8495460 | 0.84 | SERPINE1 (0.54) | SERPINE1HRH3ALDH1A1DNM1MAOB | |
| SCHEMBL8490817 | 0.84 | SERPINE1 (0.60) | SERPINE1HRH3ALDH1A1DNM1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902812-A | Pharmaceutical piperazine compounds | XENOVA LIMITED (GB) | 1999-05-11 | — | — | US | disclosed |
| WO-1995021829-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |