Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.73 |
| ▸ | MAPT | P10636 | 7/20 | 0.73 |
| ▸ | MEN1 | O00255 | 6/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | CASP3 | P42574 | 1/20 | 0.73 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.73 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.73 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8494191 | 1.00 | KMT2A (0.73) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL23046856 | 0.90 | KMT2A (0.68) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL2940762 | 0.89 | MEN1 (0.76) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL14756766 | 0.89 | MAPT (0.71) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL2940766 | 0.89 | MEN1 (0.76) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL23046854 | 0.87 | KMT2A (0.69) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL17529416 | 0.87 | KMT2A (0.69) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL22713034 | 0.86 | KMT2A (0.68) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL15984842 | 0.84 | KMT2A (0.66) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL23600586 | 0.84 | MEN1 (0.66) | KMT2AMAPTMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |