Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 8/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8494618 | 1.00 | HRH3 (0.45) | HRH3SERPINE1PSEN1PSEN2APH1B | |
| SCHEMBL9015020 | 0.85 | SERPINE1 (0.56) | HRH3SERPINE1PSEN1PSEN2APH1B | |
| SCHEMBL9015027 | 0.85 | SERPINE1 (0.56) | HRH3SERPINE1PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL8494465 | 0.84 | SERPINE1 (0.55) | HRH3SERPINE1PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL8494449 | 0.84 | SERPINE1 (0.55) | HRH3SERPINE1PSEN1PSEN2APH1B | |
| SCHEMBL8495799 | 0.83 | KDM4E (0.53) | HRH3SERPINE1MAOB | |
| SCHEMBL8495802 | 0.83 | KDM4E (0.53) | HRH3SERPINE1MAOB | |
| SCHEMBL6371854 | 0.82 | SERPINE1 (0.60) | SERPINE1 | |
| SCHEMBL6371858 | 0.82 | SERPINE1 (0.60) | SERPINE1 | |
| SCHEMBL6375596 | 0.81 | SERPINE1 (0.65) | HRH3SERPINE1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902812-A | Pharmaceutical piperazine compounds | XENOVA LIMITED (GB) | 1999-05-11 | — | — | US | claimed |
| US-5902812-A | Pharmaceutical piperazine compounds | XENOVA LIMITED (GB) | 1999-05-11 | — | — | US | disclosed |
| EP-0745069-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995021829-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |