Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PTGES | O14684 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8826048 | 1.00 | TSHR (0.56) | TSHRHSD17B10PTGESKDM4EALOX5 | |
| SCHEMBL8493650 | 1.00 | TSHR (0.56) | TSHRHSD17B10PTGESKDM4EALOX5 | |
| SCHEMBL8826050 | 1.00 | TSHR (0.56) | TSHRHSD17B10PTGESKDM4EALOX5 | |
| SCHEMBL8826180 | 0.89 | LPAR1 (0.49) | — | |
| SCHEMBL8497624 | 0.89 | LPAR1 (0.49) | — | |
| SCHEMBL8826185 | 0.89 | LPAR1 (0.49) | — | |
| SCHEMBL8497626 | 0.89 | LPAR1 (0.49) | — | |
| SCHEMBL8493909 | 0.89 | LPAR1 (0.51) | — | |
| SCHEMBL8493183 | 0.89 | LPAR1 (0.51) | — | |
| SCHEMBL8825925 | 0.89 | LPAR1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| WO-1996034850-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |