Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028129 | 0.81 | TDP1 (0.46) | TDP1ALDH1A1CYP1A2CYP2A6TP53 | |
| SCHEMBL8502547 | 0.79 | TDP1 (0.44) | TDP1ALDH1A1CYP1A2CYP2A6TP53 | |
| SCHEMBL1031939 | 0.77 | TDP1 (0.42) | TDP1ALDH1A1CYP1A2CYP2A6TP53 | |
| SCHEMBL1030327 | 0.77 | TDP1 (0.42) | TDP1ALDH1A1CYP1A2CYP2A6TP53 | |
| SCHEMBL1031216 | 0.77 | TDP1 (0.42) | TDP1ALDH1A1CYP1A2CYP2A6TP53 | |
| SCHEMBL1030428 | 0.77 | TDP1 (0.42) | TDP1ALDH1A1CYP1A2CYP2A6TP53 | |
| SCHEMBL15529813 | 0.73 | TDP1 (0.39) | TDP1ALDH1A1CYP1A2CYP2A6TP53 | |
| SCHEMBL15529745 | 0.73 | TDP1 (0.39) | TDP1ALDH1A1CYP1A2CYP2A6TP53 | |
| SCHEMBL15529622 | 0.73 | TDP1 (0.39) | TDP1ALDH1A1CYP1A2CYP2A6TP53 | |
| SCHEMBL15529912 | 0.72 | CYP2A6 (0.38) | TDP1ALDH1A1CYP1A2CYP2A6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5795889-A | INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5656643-A | QUINOLIN PYRIDINE DERIVATIVES; USEFUL FOR TREATING CANCER, LEKEMIA, PSORIASIS, INFLAMMATORY DISODERS, BONE DISORDERS, ATHEROSCLEROSIS AND RESTENOSIS; CONTROLLS CELLULAR REPRODUCTION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |
| US-5409930-A | Inhibits abnoramal cell proliferation; dimethoxyquinoline/ dimethylquinoline/ quinolineoxide/ and quinoxaline derivatives | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-04-25 | — | — | US | disclosed |
| WO-1992020642-A1 | BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-11-26 | — | — | WO | disclosed |
| US-4316853-A | Insecticidal tetraorganotin compounds | M&T CHEMICALS INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0001717-B1 | INSECTICIDAL COMPOSITIONS CONTAINING TETRAORGANOTIN COMPOUNDS AND METHOD FOR USING SAME | M & T CHEMICALS, INC. (US) | 1981-11-04 | — | — | EP | disclosed |
| EP-0001716-B1 | TETRA-ORGANOTIN COMPOUNDS IN WHICH THE TIN IS BONDED TO THREE METHYL GROUPS AND IS BONDED DIRECTLY OR THROUGH A METHYLENE GROUP TO A BENZENE RING OR HETEROCYCLIC RADICAL | M & T CHEMICALS, INC. (US) | 1981-09-16 | — | — | EP | disclosed |
| US-4212810-A | INSECTICIDES | M&T CHEMICALS INC. (US) | 1980-07-15 | — | — | US | disclosed |
| US-4212885-A | Insecticidal compositions containing certain tetraorganotin compounds and method for using same | M&T CHEMICALS INC. (US) | 1980-07-15 | — | — | US | disclosed |
| EP-0001717-A2 | Insecticidal compositions containing tetraorganotin compounds and method for using same | M & T CHEMICALS, INC. (US) | 1979-05-02 | — | — | EP | disclosed |