Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 8/20 | 0.50 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | TACR2 | P21452 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SHBG | P04278 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501636 | 1.00 | SPHK1 (0.50) | SPHK1SPHK2S1PR1S1PR2HTR2A | |
| SCHEMBL8503490 | 1.00 | SPHK1 (0.50) | SPHK1SPHK2S1PR1S1PR2HTR2A | |
| SCHEMBL8504675 | 0.93 | SPHK1 (0.47) | SPHK1SPHK2S1PR1S1PR2HTR2A | |
| SCHEMBL8501701 | 0.93 | SPHK1 (0.54) | SPHK1S1PR1S1PR2HTR2AS1PR3 | |
| Hydrochloric Acid SCHEMBL8501922 | 0.92 | SPHK1 (0.46) | SPHK1SPHK2S1PR1S1PR2HTR2A | |
| Hydrochloric Acid SCHEMBL8503317 | 0.92 | SPHK1 (0.48) | SPHK1SPHK2S1PR1S1PR2HTR2A | |
| Hydrochloric Acid SCHEMBL8501504 | 0.92 | SPHK1 (0.52) | SPHK1S1PR1S1PR2HTR2AS1PR3 | |
| SCHEMBL14246903 | 0.85 | S1PR1 (0.62) | S1PR1S1PR2S1PR3S1PR4 | |
| SCHEMBL8504679 | 0.84 | SPHK1 (0.51) | SPHK1SPHK2S1PR1S1PR2HTR2A | |
| SCHEMBL8503314 | 0.84 | SPHK1 (0.51) | SPHK1SPHK2S1PR1S1PR2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948820-A | IMMUNOSUPPRESSANT; PREVENT REJECTION OF ORGAN TRANSPLANT;AUTOIMMUNE DISEASES; MULTIPLE SCLEROSIS; LUPUS; ANTIALLERGENS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-07 | — | — | US | disclosed |