Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Abietic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.88 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.88 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.88 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.88 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.88 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.88 |
| ▸ | LMNA | P02545 | 2/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.88 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.88 |
| ▸ | MAPT | P10636 | 2/20 | 0.88 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.88 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.88 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.88 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.88 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.88 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Abietic Acid SCHEMBL8503031 | 1.00 | HSD17B10 (0.88) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| Abietic Acid SCHEMBL30366100 | 0.95 | HSD17B10 (0.86) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| Abietic Acid SCHEMBL8898401 | 0.94 | HSD17B10 (0.92) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| Abietic Acid SCHEMBL8740558 | 0.94 | HSD17B10 (0.92) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| Abietic Acid SCHEMBL19798150 | 0.94 | HSD17B10 (1.00) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| Abietic Acid SCHEMBL28888 | 0.94 | HSD17B10 (1.00) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| Abietic Acid SCHEMBL10038576 | 0.94 | HSD17B10 (1.00) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| Abietic Acid SCHEMBL9892651 | 0.94 | HSD17B10 (1.00) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| Abietic Acid SCHEMBL678976 | 0.94 | HSD17B10 (1.00) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| Abietic Acid SCHEMBL14700492 | 0.94 | HSD17B10 (1.00) | HSD17B10ALOX15PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5992354-A | Combustion of nanopartitioned fuel | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1997003279-A9 | COMBUSTION OF NANOPARTITIONED FUEL | — | 1997-03-06 | — | — | WO | disclosed |
| WO-1997003279-A1 | COMBUSTION OF NANOPARTITIONED FUEL | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1997-01-30 | — | — | WO | disclosed |