Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.66 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.66 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520725 | 0.99 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL9847397 | 0.99 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL26771259 | 0.81 | CYSLTR1 (0.92) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL10547998 | 0.80 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL13772898 | 0.80 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL26774846 | 0.80 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL13772899 | 0.80 | PDE10A (0.73) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10544473 | 0.80 | CYSLTR1 (0.84) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL6583310 | 0.79 | CYSLTR1 (0.78) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL26773167 | 0.78 | CYSLTR1 (0.65) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743312-B1 | Spiroheterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-11-17 | — | — | EP | disclosed |
| EP-0743312-A1 | Spiroheterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-11-20 | — | — | EP | disclosed |
| EP-0414078-A2 | Disubstituted (quinolin-2-yl-methoxy)-phenylacetic acid derivatives | BAYER AG (DE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0344519-A1 | Substituted 4-(quinolin-2-yl-methoxy)phenyl-acetic-acid derivatives | BAYER AG (DE) | 1989-12-06 | — | — | EP | disclosed |