Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.71 |
| ▸ | ARG2 | P78540 | 4/20 | 0.46 |
| ▸ | ARG1 | P05089 | 3/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL8508901 | 1.00 | GSR (0.71) | GSRARG2ARG1CPB2RNPEP | |
| Aspartic Acid SCHEMBL8508899 | 1.00 | GSR (0.71) | GSRARG2ARG1CPB2RNPEP | |
| Aspartic Acid SCHEMBL8508699 | 1.00 | GSR (0.71) | GSRARG2ARG1CPB2RNPEP | |
| Lysine SCHEMBL614905 | 0.98 | GSR (0.74) | GSRARG2ARG1CPB2RNPEP | |
| Lysine SCHEMBL2589784 | 0.94 | GSR (0.80) | GSRARG2ARG1CPB2RNPEP | |
| Lysine SCHEMBL18528930 | 0.94 | GSR (0.80) | GSRARG2ARG1CPB2RNPEP | |
| Lysine SCHEMBL20952564 | 0.94 | GSR (0.80) | GSRARG2ARG1CPB2RNPEP | |
| Lysine SCHEMBL1425215 | 0.94 | GSR (0.80) | GSRARG2ARG1CPB2RNPEP | |
| Lysine SCHEMBL1425217 | 0.94 | GSR (0.80) | GSRARG2ARG1CPB2RNPEP | |
| Lysine SCHEMBL31679370 | 0.94 | GSR (0.80) | GSRARG2ARG1CPB2RNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938497-A1 | CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME | Genentech, Inc. (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998020036-A1 | CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME | GENENTECH, INC. (US) | 1998-05-14 | — | — | WO | disclosed |