Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 9/20 | 0.43 |
| ▸ | CASP9 | P55211 | 1/20 | 0.43 |
| ▸ | BIRC2 | Q13490 | 9/20 | 0.37 |
| ▸ | BIRC3 | Q13489 | 4/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8512115 | 0.92 | XIAP (0.41) | XIAPCASP9BIRC2BIRC3TNF | |
| SCHEMBL8512165 | 0.91 | XIAP (0.48) | XIAPCASP9BIRC2BIRC3TNF | |
| SCHEMBL8510474 | 0.91 | XIAP (0.47) | XIAPCASP9BIRC2BIRC3TNF | |
| SCHEMBL9613405 | 0.91 | XIAP (0.48) | XIAPCASP9BIRC2BIRC3TNF | |
| SCHEMBL9613517 | 0.91 | XIAP (0.47) | XIAPCASP9BIRC2BIRC3TNF | |
| SCHEMBL8510538 | 0.90 | BIRC2 (0.41) | XIAPCASP9BIRC2BIRC3TNF | |
| SCHEMBL8509763 | 0.87 | XIAP (0.40) | XIAPBIRC2BIRC3TNF | |
| SCHEMBL8512112 | 0.82 | XIAP (0.45) | XIAPCASP9BIRC2BIRC3CYP2C19 | |
| SCHEMBL9613409 | 0.82 | XIAP (0.45) | XIAPCASP9BIRC2BIRC3CYP2C19 | |
| SCHEMBL8511549 | 0.82 | XIAP (0.43) | XIAPCASP9BIRC2BIRC3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415486-B2 | IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2013-04-09 | — | — | US | disclosed |
| US-20120135990-A1 | IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135990-A1 | IAP INHIBITORS | XIAP, IAPP, BIRC5 | XIAP 1/4885CASP9 63/4885BIRC2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.