Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.42 |
| ▸ | ITGAL | P20701 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8511506 | 0.88 | ITGB2 (0.47) | CKS1BSKP1SKP2ITGB2ICAM1 | |
| SCHEMBL8510959 | 0.88 | CKS1B (0.44) | CKS1BSKP1SKP2ITGB2ICAM1 | |
| SCHEMBL8514665 | 0.86 | CKS1B (0.48) | CKS1BSKP1SKP2ITGB2ICAM1 | |
| SCHEMBL8514087 | 0.85 | PDE4B (0.43) | CKS1BSKP1SKP2ITGB2ICAM1 | |
| SCHEMBL8510649 | 0.85 | CKS1B (0.45) | CKS1BSKP1SKP2ITGB2ICAM1 | |
| SCHEMBL8510956 | 0.85 | CKS1B (0.47) | CKS1BSKP1SKP2ITGB2ICAM1 | |
| SCHEMBL8515235 | 0.84 | CKS1B (0.46) | CKS1BSKP1SKP2ITGB2ICAM1 | |
| SCHEMBL8511472 | 0.83 | PDE4D (0.51) | CKS1BSKP1SKP2ITGB2ICAM1 | |
| SCHEMBL8513238 | 0.83 | CKS1B (0.47) | CKS1BSKP1SKP2ITGB2ICAM1 | |
| SCHEMBL8514572 | 0.81 | CKS1B (0.45) | CKS1BSKP1SKP2ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |