Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP1 | P63208 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510649 | 0.90 | CKS1B (0.45) | CKS1BSKP1SKP2MAP4K4ITGB2 | |
| SCHEMBL8514027 | 0.89 | CKS1B (0.46) | CKS1BSKP1SKP2MAP4K4ITGB2 | |
| SCHEMBL8515036 | 0.88 | CKS1B (0.45) | CKS1BSKP1SKP2MAP4K4ITGB2 | |
| SCHEMBL8510925 | 0.88 | CKS1B (0.45) | CKS1BSKP1SKP2MAP4K4ITGB2 | |
| SCHEMBL8514133 | 0.83 | CKS1B (0.48) | CKS1BSKP1SKP2MAP4K4RET | |
| SCHEMBL8515307 | 0.82 | CKS1B (0.44) | CKS1BSKP1SKP2MAP4K4ITGB2 | |
| Hydrochloric Acid SCHEMBL8514424 | 0.82 | PIM1 (0.41) | MEN1KMT2A | |
| SCHEMBL8511506 | 0.80 | ITGB2 (0.47) | CKS1BSKP1SKP2MAP4K4ITGB2 | |
| SCHEMBL8515235 | 0.80 | CKS1B (0.46) | CKS1BSKP1SKP2MAP4K4ITGB2 | |
| SCHEMBL8514665 | 0.80 | CKS1B (0.48) | CKS1BSKP1SKP2MAP4K4ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |