Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 9/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8512252 | 0.92 | BACE1 (0.36) | AKR1B1BACE1CTSD | |
| SCHEMBL2371832 | 0.91 | BACE1 (0.34) | BACE1CTSD | |
| SCHEMBL2370550 | 0.89 | BACE1 (0.32) | BACE1CTSD | |
| SCHEMBL9611302 | 0.82 | BACE1 (0.35) | AKR1B1BACE1CTSD | |
| SCHEMBL12213462 | 0.81 | BACE1 (0.30) | BACE1 | |
| SCHEMBL12472024 | 0.77 | BACE1 (0.38) | BACE1 | |
| SCHEMBL15441330 | 0.77 | BACE1 (0.38) | BACE1 | |
| SCHEMBL12471352 | 0.77 | BACE1 (0.38) | BACE1 | |
| SCHEMBL15418574 | 0.74 | BACE1 (0.34) | AKR1B1BACE1CTSD | |
| SCHEMBL12471226 | 0.73 | BACE1 (0.41) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643325-A1 | SPIRO-AMINO-IMIDAZOLONE AND SPIRO-AMINO-DIHYDRO-PYRIMIDINONE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2547686-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2012071279-A1 | SPIRO-AMINO-IMIDAZOLONE AND SPIRO-AMINO-DIHYDRO-PYRIMIDINONE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2012-05-31 | — | — | WO | disclosed |