Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 20/20 | 0.79 |
| ▸ | PIM1 | P11309 | 19/20 | 0.79 |
| ▸ | PIM2 | Q9P1W9 | 19/20 | 0.79 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13458218 | 0.92 | PIM3 (0.80) | PIM3PIM1PIM2 | |
| SCHEMBL13458375 | 0.92 | PIM3 (0.80) | PIM3PIM1PIM2 | |
| SCHEMBL14235348 | 0.91 | PIM3 (0.90) | PIM3PIM1PIM2GSK3BPRKCQ | |
| SCHEMBL3207103 | 0.88 | PIM3 (1.00) | PIM3PIM1PIM2GSK3BPRKCQ | |
| SCHEMBL3207094 | 0.88 | PIM3 (1.00) | PIM3PIM1PIM2GSK3BPRKCQ | |
| SCHEMBL3227394 | 0.88 | PIM3 (1.00) | PIM3PIM1PIM2GSK3BPRKCQ | |
| SCHEMBL3220616 | 0.86 | PIM3 (1.00) | PIM3PIM1PIM2 | |
| SCHEMBL3208976 | 0.86 | PIM3 (1.00) | PIM3PIM1PIM2 | |
| SCHEMBL13458206 | 0.85 | PIM3 (0.83) | PIM3PIM1PIM2 | |
| SCHEMBL3218257 | 0.85 | PIM3 (1.00) | PIM3PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592455-B2 | Kinase inhibitors and methods of their use | NOVARTIS AG (CH) | 2013-11-26 | — | — | US | disclosed |
| US-20120134987-A1 | KINASE INHIBITORS AND METHODS OF THEIR USE | BURGER MATTHEW T (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120134987-A1 | KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | PIM3 3/4885PIM1 1/4885PIM2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.