Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.40 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.35 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8514921 | 1.00 | S1PR1 (0.40) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL8510394 | 0.92 | S1PR1 (0.44) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL8510397 | 0.92 | S1PR1 (0.44) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL8512090 | 0.91 | S1PR1 (0.44) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL8512084 | 0.91 | S1PR1 (0.44) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL8513520 | 0.91 | S1PR1 (0.46) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL8510815 | 0.91 | S1PR1 (0.44) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL8510811 | 0.91 | S1PR1 (0.44) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL8513513 | 0.91 | S1PR1 (0.46) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL8513772 | 0.89 | S1PR1 (0.39) | S1PR1TNNC1S1PR3S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309768-B2 | FTY720-derived anticancer agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-11-13 | — | — | US | disclosed |
| US-20120136063-A1 | FTY720-DERIVED ANTICANCER AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136063-A1 | FTY720-DERIVED ANTICANCER AGENTS | SPHK2, S1PR2, S1PR1 | S1PR1 3/4885TNNC1 4860/4885S1PR3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.