SCHEMBL8515230

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL8586856	1.00	RPS6KB1 (0.82)	RPS6KB1AKT1AURKBINCENPAKT2
	SCHEMBL17865859	0.93	AKT1 (0.82)	RPS6KB1AKT1AURKBINCENPAKT2
	SCHEMBL8512442	0.91	AKT1 (0.82)	RPS6KB1AKT1AURKBINCENPAKT2
	Rupitasertib SCHEMBL18537702	0.90	RPS6KB1 (1.00)	RPS6KB1AKT1AURKBINCENPAKT2
	Rupitasertib SCHEMBL30274685	0.90	RPS6KB1 (1.00)	RPS6KB1AKT1AURKBINCENPAKT2
	Rupitasertib SCHEMBL15262358	0.90	RPS6KB1 (1.00)	RPS6KB1AKT1AURKBINCENPAKT2
	Rupitasertib SCHEMBL29603841	0.90	RPS6KB1 (1.00)	RPS6KB1AKT1AURKBINCENPAKT2
	SCHEMBL17865834	0.89	AKT1 (0.67)	RPS6KB1AKT1AURKBINCENPAKT2
	SCHEMBL17076905	0.88	AKT1 (1.00)	RPS6KB1AKT1AURKBINCENP
	SCHEMBL20178065	0.88	AKT1 (1.00)	RPS6KB1AKT1AURKBINCENP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.