Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PI4KA | P42356 | 2/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | GAK | O14976 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515478 | 0.92 | PIK3CA (0.34) | PIK3CARENPIK3CDPIK3CBPI4KA | |
| SCHEMBL8513540 | 0.92 | PIK3CA (0.35) | PIK3CAPIK3CDPIK3CBPI4KAPI4KB | |
| SCHEMBL15407411 | 0.90 | PIK3CA (0.36) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL8586828 | 0.89 | PIK3CA (0.38) | PIK3CAPI4KAPI4KBMTORPRKDC | |
| SCHEMBL8513032 | 0.87 | PIK3CA (0.35) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL8513123 | 0.86 | PIK3CA (0.38) | PIK3CAPIK3CDPIK3CBPI4KAPI4KB | |
| SCHEMBL8515672 | 0.84 | PIK3CA (0.34) | PIK3CAMTORFTOPRKDCGAK | |
| SCHEMBL8534182 | 0.84 | PIK3CA (0.36) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL3760973 | 0.84 | PIK3CA (0.31) | PIK3CAPIK3CDPIK3CBPI4KAPI4KB | |
| SCHEMBL15407782 | 0.83 | PIK3CA (0.36) | PIK3CAPIK3CDPIK3CBPI4KAPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643327-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012071511-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-31 | — | — | WO | disclosed |