SCHEMBL8518

SCHEMBL8518

c1ccc2c(c1)OCCO2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB2 P05107 1/20 1.00
ICAM1 P05362 1/20 1.00
ITGAL P20701 1/20 1.00
SMN1; SMN2 Q16637 3/20 0.82
LMNA P02545 3/20 0.82
CRHBP P24387 2/20 0.82
CRHR2 Q13324 2/20 0.82
HTT P42858 2/20 0.82
ABCG2 Q9UNQ0 1/20 0.65
GAA P10253 2/20 0.54
KDM4E B2RXH2 1/20 0.45
MAOA P21397 2/20 0.43
MAOB P27338 2/20 0.43
NOTUM Q6P988 1/20 0.43
MAPT P10636 2/20 0.42
BLM P54132 1/20 0.42
PDK1 Q15118 1/20 0.42
ADRB1 P08588 1/20 0.42
KEAP1 Q14145 1/20 0.41
RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11519392 1.00 ITGB2 (1.00) ITGB2ICAM1ITGALSMN1; SMN2LMNA
SCHEMBL29997436 1.00 ITGB2 (1.00) ITGB2ICAM1ITGALSMN1; SMN2LMNA
SCHEMBL6791411 1.00 ITGB2 (1.00) ITGB2ICAM1ITGALSMN1; SMN2LMNA
SCHEMBL11399163 1.00 ITGB2 (1.00) ITGB2ICAM1ITGALSMN1; SMN2LMNA
SCHEMBL11406989 1.00 ITGB2 (1.00) ITGB2ICAM1ITGALSMN1; SMN2LMNA
SCHEMBL27796077 1.00 ITGB2 (1.00) ITGB2ICAM1ITGALSMN1; SMN2LMNA
SCHEMBL28311086 0.97 ITGB2 (0.93) ITGB2ICAM1ITGALSMN1; SMN2LMNA
Methane SCHEMBL28630381 0.97 ITGB2 (0.93) ITGB2ICAM1ITGALSMN1; SMN2LMNA
Benzene SCHEMBL28072178 0.97 ITGB2 (0.93) ITGB2ICAM1ITGALSMN1; SMN2LMNA
SCHEMBL11557715 0.97 ITGB2 (0.93) ITGB2ICAM1ITGALSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 26691 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362369-B1 None US claimed
EP-3704090-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-05-27 EP claimed
CN-122036610-A Synthesis method of central chiral aza seven-membered bridged aromatic compound containing chiral axis 浙江大学 2026-05-15 CN claimed
US-12590100-B2 Tetrahydro-spiroindoline-pyrrolopyrrole-triones inhibitors of the NRF2-β-TrCP interaction for use in the treatment of fatty liver disease UNIV MADRID AUTONOMA (ES) 2026-03-31 US claimed
US-20260078296-A1 SUSTAINED-RELEASE SCALE INHIBITORS Materials Engineering and Technical Support Services (US) 2026-03-19 US claimed
US-20260069599-A1 INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 AND PHOSPHOINOSITIDE 3-KINASE UNIV NEBRASKA (US) 2026-03-12 US claimed
WO-2025264581-A1 P110 INHIBITORS FOR THE TREATMENT OF CANCER LEAPFROG BIO, INC. (US) 2025-12-26 WO claimed
US-20250388544-A1 HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES VIVORYON THERAPEUTICS N.V. (DE) 2025-12-25 US claimed
EP-4667451-A1 PESTICIDALLY-ACTIVE 2,2-DIHALOCYCLOPROPYL COMPOUNDS Syngenta Crop Protection AG (CH) 2025-12-24 EP claimed
EP-4658655-A1 CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITOR OF DIACYLGLYCEROL KINASES Beone Medicines I GmbH (CH) 2025-12-10 EP claimed
WO-1983003607-A1 NEW CYANOGUANIDINES, METHOD FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM CORNU, PIERRE-JEAN 1983-10-27 WO claimed
US-4376728-A Process for the preparation of cationic alkylarylhydrazone dyestuffs and color bases thereof BAYER AKTIENGESELLSCHAFT (DE) 1983-03-15 US claimed
US-4358572-A POLYMERIZATION OF ALPH-OLEFINS USING A CATALYTIC SLURRY OF TITANIUM HALIDE, HYDROCARBON DILUENT, ETHER, AND ALUMINUM COMPOUND CONOCO INC. (US) 1982-11-09 US claimed
EP-0004366-B1 HAIR DYEING COMPOSITIONS Henkel Kommanditgesellschaft auf Aktien (DE) 1981-07-08 EP claimed
EP-0004435-B1 ETHERS OF 4-HALOMETHYLPYRIDINES, FUNGICIDAL COMPOSITIONS AND METHOD FOR PROTECTING PLANTS FROM FUNGAL DISEASE THE DOW CHEMICAL COMPANY (US) 1981-07-01 EP claimed
EP-0003359-B1 SPECIFIC OPTICAL ISOMERS OF 2-AMINOETHYL-1,4-BENZODIOXANES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS CIBA-GEIGY AG (CH) 1981-02-11 EP claimed
US-4217305-A HYPOTENSIVE AGENTS, ADRENERGIC BLOCKING AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1980-08-12 US claimed
US-4100291-A HYPOTENSIVE ROUSSEL UCLAF (FR) 1978-07-11 US claimed
US-4003746-A Organic heterocyclic and thioaryl phosphines in silver halide emulsions and developers therefor E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-01-18 US claimed
US-3967835-A Pressure-sensitive copying material HODOGAYA CHEMICAL CO., LTD. (JA) 1976-07-06 US claimed