Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 4/20 | 0.49 |
| ▸ | CES2 | O00748 | 3/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2941326 | 0.98 | RECQL (0.62) | RECQLLMNATDP1CES1CES2 | |
| SCHEMBL1375933 | 0.98 | RECQL (0.62) | RECQLLMNATDP1CES1CES2 | |
| Oxalic Acid SCHEMBL10792364 | 0.95 | RECQL (0.58) | RECQLLMNATDP1CES1CES2 | |
| SCHEMBL2946253 | 0.93 | RECQL (0.60) | RECQLLMNATDP1CES1CES2 | |
| SCHEMBL2946252 | 0.93 | RECQL (0.60) | RECQLLMNATDP1CES1CES2 | |
| SCHEMBL2941701 | 0.92 | TDP1 (0.60) | RECQLLMNATDP1CES1CES2 | |
| SCHEMBL2941695 | 0.92 | TDP1 (0.60) | RECQLLMNATDP1CES1CES2 | |
| SCHEMBL1535093 | 0.90 | TDP1 (0.59) | RECQLLMNATDP1CES1CES2 | |
| SCHEMBL3146136 | 0.88 | RECQL (0.66) | RECQLLMNATDP1CES1CES2 | |
| SCHEMBL3146140 | 0.88 | RECQL (0.66) | RECQLLMNATDP1CES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5868261-A | Anti-slamming latch apparatus for modular component installations | DIGITAL EQUIPMENT CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0843510-A2 | Anti-slamming latching apparatus for modular component installations | DIGITAL EQUIPMENT CORPORATION (US) | 1998-05-20 | — | — | EP | disclosed |