Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 10/20 | 0.81 |
| ▸ | RARG | P13631 | 10/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.81 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.81 |
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RARA | P10276 | 9/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29354207 | 0.89 | RARB (1.00) | RARBRARGCYP3A4CYP26A1RXRA | |
| SCHEMBL29613246 | 0.89 | RARB (1.00) | RARBRARGCYP3A4CYP26A1RXRA | |
| SCHEMBL30477013 | 0.89 | RARB (1.00) | RARBRARGCYP3A4CYP26A1RXRA | |
| SCHEMBL3756112 | 0.89 | RARB (1.00) | RARBRARGCYP3A4CYP26A1RXRA | |
| SCHEMBL165751 | 0.89 | RARB (1.00) | RARBRARGCYP3A4CYP26A1RXRA | |
| SCHEMBL165750 | 0.89 | RARB (1.00) | RARBRARGCYP3A4CYP26A1RXRA | |
| SCHEMBL2788640 | 0.75 | CYP3A4 (0.70) | RARBRARGCYP3A4CYP26A1RXRA | |
| SCHEMBL5080286 | 0.74 | RARB (0.71) | RARBRARGCYP3A4CYP26A1RXRA | |
| SCHEMBL8839311 | 0.74 | RARG (0.50) | RARBRARGCYP3A4CYP26A1RXRA | |
| SCHEMBL6343446 | 0.71 | CYP3A4 (0.44) | RARBRARGCYP3A4CYP26A1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747347-B1 | RAR-gamma-specific retinobenzoic acid derivatives | BRISTOL MYERS SQUIBB CO (US) | 1999-07-21 | — | — | EP | disclosed |
| US-5624957-A | RETINOID ACTIVE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0747347-A1 | RARy-specific retinobenzoic acid derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |