Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | IGF2R | P11717 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8519728 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL6609046 | 0.88 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL6609041 | 0.88 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL6609611 | 0.87 | PDE4B (0.43) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL6609617 | 0.87 | PDE4B (0.43) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL6606116 | 0.87 | MAPT (0.47) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL6606109 | 0.87 | MAPT (0.47) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL8484322 | 0.83 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL8484327 | 0.83 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL6605953 | 0.81 | KDM4E (0.53) | PDE4DPDE4APDE4BPDE4CEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |