Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.50 |
| ▸ | PDE4A | P27815 | 12/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146817 | 1.00 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL146818 | 1.00 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL5184516 | 0.89 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7414607 | 0.89 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7414604 | 0.89 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7786887 | 0.89 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6197797 | 0.88 | PDE4B (0.59) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL6196613 | 0.88 | PDE4B (0.59) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL6196611 | 0.88 | PDE4B (0.59) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL5306792 | 0.87 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121615-B1 | NAPADISYLATE SALT OF 5-(2-{[6-(2,2-DIFLUORO-2-PHENYLETHOXY)HEXYL]AMINO}-1-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE AS AGONIST OF THE BETA 2 ADRENERGIC RECEPTOR | ALMIRALL SA (ES) | 2012-03-28 | — | — | EP | claimed |
| EP-0636026-B1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORP (US) | 2001-12-05 | — | — | EP | claimed |
| EP-0636026-B1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORP (US) | 2001-12-05 | — | — | EP | disclosed |
| US-5605923-A | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |