SCHEMBL8522135

SCHEMBL8522135

[CH2]C(c1ccccc1)(c1ccccc1)c1ccc(OC)cc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA4 P22748 1/20 0.54
LTA4H P09960 2/20 0.52
KIF11 P52732 9/20 0.51
KCNH2 Q12809 1/20 0.51
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
TRPA1 O75762 1/20 0.47
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
BACE1 P56817 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9595065 1.00 CA4 (0.54) CA4LTA4HKIF11KCNH2CA12
SCHEMBL8858901 0.82 CA4 (0.59) CA4LTA4HKIF11KCNH2CA12
SCHEMBL8648265 0.82 CA4 (0.59) CA4LTA4HKIF11KCNH2CA12
SCHEMBL5051055 0.82 CA4 (0.59) CA4LTA4HKIF11KCNH2CA12
SCHEMBL10112758 0.82 CA4 (0.59) CA4LTA4HKIF11KCNH2CA12
SCHEMBL1286989 0.82 CA4 (0.59) CA4LTA4HKIF11KCNH2CA12
SCHEMBL14856630 0.82 CA4 (0.59) CA4LTA4HKIF11KCNH2CA12
SCHEMBL6787449 0.80 CA4 (0.56) CA4LTA4HKIF11KCNH2CA12
SCHEMBL7021665 0.80 CA4 (0.56) CA4LTA4HKIF11KCNH2CA12
SCHEMBL4570566 0.80 CA4 (0.56) CA4LTA4HKIF11KCNH2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992011276-A1 NOVEL SYNTHESIS OF 2'-'UP' FLUORINATED 2''-DEOXY-ARABINOFURANOSYLPURINES SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1992-07-09 WO claimed
US-5859042-A ALOPECIA, ACNE, DISEASES OF THE PROSTATE GLANDS ONO PHARMACEUTICAL CO., LTD. (JP) 1999-01-12 US disclosed
WO-1992011276-A1 NOVEL SYNTHESIS OF 2'-'UP' FLUORINATED 2''-DEOXY-ARABINOFURANOSYLPURINES SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1992-07-09 WO disclosed